Abstract

CAVIEDES RUBIO, Diego Iván; SOTOMAYOR PINO, Reinaldo Gabriel  and  DELGADO, Daniel Ricardo. Preferential solvation of naringin in ethanol + water cosolvent mixtures according with the inverse Kirkwood-Buff integrals. Rev. colomb. cienc. quim. farm. [online]. 2015, vol.44, n.2, pp.220-235. ISSN 0034-7418.  https://doi.org/10.15446/rcciquifa.v44n2.56295.

The preferential solvation parameters, i.e., the differences between the local and bulk mole fractions of the solvents in solutions of naringin is derived from their solubility in binary solvent mixtures by means of the inverse Kirkwood-Buff integral (IKBI) method. According to IKBI method it is found that naringin is sensitive to solvation effects, so the preferential solvation parameter by ethanol δx_1,3, is negative in waterrich and ethanol-rich mixtures but positive in compositions from 0.24 to 0.40 in mole fraction of ethanol. This could demonstrate the relevant role of hydrophobic hydration around the non-polar groups in the drug solvation in water-rich mixtures. Otherwise, in mixtures of intermediate co-solvent compositions, the drug is mainly solvated by ethanol, probably due to the basic behavior of the co-solvents; whereas, in ethanol-rich mixtures, the preferential solvation by water could be due to the acidic behavior of water.

Keywords : Naringin; solubility; inverse Kirkwood-Buff integrals; IKBI; preferential solvation.

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