Resumo

SANDOVAL, Plinio A; RAJABI-SIAHBOOMI, Ali  e  PONCE D'LEON, Luisa Fernanda. A comparative analysis of the release kinetics of sodium diclofenac from hydrophilic matrices in conventional dissolution media and biorelevant media is carried out. Rev. colomb. cienc. quim. farm. [online]. 2015, vol.44, n.3, pp.282-310. ISSN 0034-7418.  https://doi.org/10.15446/rcciquifa.v44n3.56282.

Two hydrophilic polymers commonly employed on the development of extended release products, hydroxypropyl-methyl-cellulose (HPMC, hypromellose) and polyethylene oxide (PEO) were formulated with microcrystalline cellulose or lactose in order to investigate the release kinetics of sodium diclofenac on USP apparatus II and III using a compendial or biorelevant media, respectively. The dominant release kinetic on apparatus II was first order and zero on apparatus III. The values of the kinetic constant (k) and the release exponent (n) from the Power Law Model indicated that there was no burst effect in none of the studied formulations, relaxation and polymer erosion was the dominant mechanism of drug release in both methods. The results suggest that biorelevant dissolution methodology is appropriate for the discrimination of formulations and prediction of in vivo performance of MR diclofenac sodium matrices.

Palavras-chave : Diclofenac; Methocel; Polyox; kinetics; biorelevant media.

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