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Revista Colombiana de Ciencias Químico - Farmacéuticas
versão impressa ISSN 0034-7418
Resumo
NAVA-MESA, Mauricio O; TELLEZ-AREVALO, Angelica; ROJAS-KOZHAKIN, Daniel e CALDERON-OSPINA, Carlos A. Potential therapeutic uses of opioid antagonists: Pathophysiology and preclinical evidence. Rev. colomb. cienc. quim. farm. [online]. 2015, vol.44, n.3, pp.322-358. ISSN 0034-7418. https://doi.org/10.15446/rcciquifa.v44n3.56284.
Opioid system, which involved endogenous opioid peptides and their receptors (Miu, Kappa, delta and ORL), has a main role in the physiology of several systems. At the same time, there is cumulating evidence in the role of the opioid system in the physiopathology of several disorders in the central nervous, endocrine and immunological system. The modulation of the opioid system using nonspecific antagonists may have a therapeutic role in the symptomatic management of several diseases, as well as, in the emergency management of opioid analgesic overdose, opioid dependence and to reduce the drug side effects of the opioid agonists used in chronic pain. This paper aims to review the pharmacology of specific and nonspecific opioid antagonists, and update on possible new indications and therapeutic uses of such antagonists.
Palavras-chave : Opiate antagonist; opioid system; opioid-related disorders.