Abstract

LILLINI, Gastón et al. Study of emulsions stability with liquid crystals structure and their pharmaceutical application by the addition of a liposoluble principe active: Econazole. Rev. colomb. cienc. quim. farm. [online]. 2016, vol.45, n.1, pp.5-20. ISSN 0034-7418.  https://doi.org/10.15446/rcciquifa.v45n1.58011.

The skin is the appropiate organ to administrate active principles in orden to obtain local or systemic effects. Formulations for topical use most common are: lotions, emulsions, suspensions, creams, ointments, which must gather certain conditions to be applied to the skin. In this work, the objective is to select an emulsion prepared by a technique of liquid crystals formation composed by stearic acid, mineral oil, triethanolamine, propylparaben, methylparaben and water. To this formula we incorporated a pharmaceutical active liposoluble ingredient: econazole. Econazole, a principle active with topical administration and local action, is a substance soluble in oils, which stays in the liposoluble fraction of the liquid crystals and in their internal phase of the emulsion without modifying their rheological profile not even the stability of systems. Besides the HLB of the systems and their rheological behaviour we also study the presence of liquid crystals with polarized light, the existence of secondary drops with common light and systems stability by centrifugation, thermal stress and temperatures of 40 °C. The values obtained from the studies made, demonstrated that the emulsion achieved present a rheological profile and stability conditions suitable for medicinal use cream.

Keywords : Lyotropic liquid crystals; Emulsions; HLB; Secondary droplets; Rheology; Econazole.

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