Abstract

CASTRO RUIZ, Jean M; VALLEJO DIAZ, Bibiana M  and  BARBOSA BARBOSA, Helber J. Design of a bioadhesive system with chlorhexidine using pullulan as matrix for use in oral mucous. Rev. colomb. cienc. quim. farm. [online]. 2016, vol.45, n.1, pp.48-76. ISSN 0034-7418.  https://doi.org/10.15446/rcciquifa.v45n1.58016.

As a therapeutic alternative in the transport of active substances in treatment of gingivitis and periodontal disease, bioadhesive polymeric systems type polymeric film and tablet were developed using the biopolymer pullulan. First, the ability of pullulan polymer to form films and tablets was evaluated and formulations were proposed for each system. Mechanical and transport properties, as well as antiseptic activity and microstructures characteristics were determined for these polymeric systems. Drug release behavior in the studied systems was also verified. The in vitro mucoadhesive capacity was determined with the formulations selected, using porcine oral mucous membrane like substrate.

Keywords : Polymer films; Bioadhesive tablets; Mucoadhesion; Pullulan.

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