Abstract

AREIZA ALDANA, Grecia Angeline del Mar et al. Solution thermodynamics and preferential solvation of 3-chloro-N-phenyl-phthalimide in acetone + methanol mixtures. Rev. colomb. cienc. quim. farm. [online]. 2016, vol.45, n.2, pp.256-274. ISSN 0034-7418.  https://doi.org/10.15446/rcciquifa.v45n2.59941.

The thermodynamic properties of the 3-chloro-N-phenyl-phthalimide in acetone + methanol cosolvent mixtures were obtained from solubility data report in literature. The solubility was higher in near acetone and lower in pure methanol at all temperatures studied. A non-linear plot of ∆_solnH° vs. ∆_solnG° shows a negative slope from pure acetone up to x₁ = 0.691. Beyond this composition, a variable positive slope is obtained with the exception of mixtures with x₁ = 0.121, x₁ = 0.272 and x₁ = 0.356 which is a not common trend in these systems. The preferential solvation of 3-chloro-N-phenyl-phthalimide by the components of the solvents was estimated by means of the inverse Kirkwood-Buff integral method, showing the 3-chloro-Nphenyl-phthalimide is preferential solvated by methanol in more polar mixtures and by acetone in less polar ones.

Keywords : 3-Chloro-N-phenylphthalimide; solubility; solution thermodynamics; activity coefficients; preferential solvation.

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