Abstract

SILVA, Eliana A  and  MARTINEZ, Jorge A. History of the metabolic study of MDPV and methylone. Proposal of a biotransformation model through fungi of the genus Cunninghamella. Rev. colomb. cienc. quim. farm. [online]. 2016, vol.45, n.3, pp.484-502. ISSN 0034-7418.  https://doi.org/10.15446/rcciquifa.v45n3.62055.

(±)-3,4-methylenedioxypyrovalerone (MDPV) and 3,4-methylendioxymethylcathi-none (methylone) are some of the most frequent synthetic derivatives of cathinones found in commercial products known as "Bath salts" and which today are used as drugs of abuse. Reports on fatal cases involving the consumption of these substances are raising and although there are some pharmacological and toxicological studies, their action mechanisms and effects due recreational consumption are not very well understood. The implementation of systems that allows the understanding of the metabolism of these drugs in humans and the design of analytical methods for their detection is now the subject of research. This paper shows a bibliographical review of the studies conducted on the biotransformation of methylone and MDPV using in vitro models with human hepatic microsomes, cell fractions S9 and in vivo models in animals with posterior analysis of the obtained metabolites. The analytical techniques used for the analysis of the metabolites include liquid chromatography coupled with mass spectrometry (LC-MS or LC-MS/MS) or the formation of acetylated or dimethyl silylated derivatives for their posterior analysis by gas chromatography (GC-MS). A proposal for the study of the metabolisms of methylone and MDPV through the fungus of the genera Cunninghamella is also included.

Keywords : MDPV; methylone; biotransformations; Cunninghamella.

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