Abstract

VALLE, Betsy; DIAZ, Jorge A.; LOPEZ, José J.  and  CALDERON, Carlos M.. Evaluation of prophylactic prescription of omeprazole and ranitidine by identifying risk factors for gastrointestinal bleeding. Rev. colomb. cienc. quim. farm. [online]. 2017, vol.46, n.1, pp.36-47. ISSN 0034-7418.  https://doi.org/10.15446/rcciquifa.v46n1.67289.

Current information on the use of inhibitors of the production of hydrochloric acid (proton-pump inhibitor (PPI) ATC A02BC and histamine H2 receptor antagonists (Anti H2) ATC A02BC) in non-critical patients for the prophylaxis of stress ulcers is controversial. A descriptive longitudinal observational study with a retrospective collection of information, that included patients over 18 years with more than three days of hospitalization in internal medicine, without active gastrointestinal bleeding using the scale of Herzig et al. {Risk factors for nosocomial gastrointestinal bleeding and use of acid-suppressive medication in non-critically ill patients, J. Gen. Intern. Med., 28(5), 683-690 (2013)}, to assess the risk gastrointestinal bleeding was carried out. According to the risk score, patients were classified 64% as low risk, 22.3% medium-low risk, 6.7% medium-high risk and 6.7% high risk. Prophylactic prescription inhibiting acid secretion was performed in 67% of patients at low risk, 57% in medium-low risk and 100% for patients with medium-high and high risk. More than half (55.33%) of the patients received a PPI/anti H2 without requiring it. Educational activities are recommended to the prescribing staff in order to make proper use of this group of drugs.

Keywords : Gastrointestinal bleeding; risk; prophylaxis; acid secretion inhibitors; acid suppression; antiulcer agents.

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