Resumo

TKACH, Volodymyr V. et al. The mechanistic theoretical evaluation of the use of cobalt (III) oxyhydroxide in electrochemical sensors of tramadol. Rev. colomb. cienc. quim. farm. [online]. 2017, vol.46, n.2, pp.188-201. ISSN 0034-7418.  https://doi.org/10.15446/rcciquifa.v46n2.67955.

The possibility of tramadol in vivo and in vitro electrochemical determination by means of the sensor, based on cobalt (III) oxyhydroxide and its composite with conducting polymers was evaluated from the mechanistic point of view. The mathematical model, correspondent to the suggested mechanism, was developed and analyzed by means of linear stability theory and bifurcation analysis. It was shown that CoO(OH) may be applied to the tramadol electrochemical determination in neutral and lightly alkaline pH values, correspondent to the more efficient oxidation of the compound. The possibility of oscillatory and monotonic instabilities has also been modified.

Palavras-chave : Drug dependence; tramadol; electrochemical sensors; cobalt oxyhydroxide; stable steady-state.

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