Abstract

MESA-VANEGAS, Ana María. Potential antiplasmodial and antimalarial agents of natural and synthetic origin. Rev. colomb. cienc. quim. farm. [online]. 2018, vol.47, n.3, pp.375-399. ISSN 0034-7418.  https://doi.org/10.15446/rcciquifa.v47n3.77371.

Malaria is the most serious and widespread parasitic disease facing humanity, due to its prevalence, virulence and the development of strains resistant to commonly used drugs such as chloroquine. The lack of affordable new drugs are the limiting factors in the fight against malaria, so there is a continuing need for research for new classes of antimalarial agents. A generation of active molecules against Plas-modium based on the mechanism of biocrystallization of the heme group and / or on metabolic processes that occur in the parasite with the medicines of current use are being synthesized and are currently in processes of in vitro, in vivo and phase I and phase II clinical studies. This review makes a classification of the new potential antimalarial and their possible modes of action reported in the last two decades in order to provide a look at the most significant progress in the development of new antimalarial drugs.

Keywords : Malaria; Plasmodium; antimalarial; chemotherapy; resistance.

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