Resumo

VASCO ZAMUDIO, Soranlly Paola; CASTRILLON CARDONA, William Fernando; MATULEVICH PELAEZ, Javier Andrés  e  DIAZ BARRERA, Laura Ximena. Phytochemical study of leaves of Cavendishia compacta (Ericaceae) and evaluation of its anti-inflammatory activity. Rev. colomb. cienc. quim. farm. [online]. 2019, vol.48, n.1, pp.61-79. ISSN 0034-7418.  https://doi.org/10.15446/rcciquifa.v48n1.80065.

The phytochemical study of leaves of Cavendishia compacta was carried out. The separation of extracts and fractions by column chromatography, thin layer and preparative thin layer allowed to obtain a mixture of diterpenes consisting of kaurane, rimunene and biformene; a mixture of aromatic compounds constituted by acetophenone and benzaldehyde; a mixture of triterpenes constituted by α -amirine and β-amirin and the isolation of morine and myricetin. The anti-inflammatory activity was evaluated to the ethanolic extract and fractions of hexane, dichloromethane and ethyl acetate using the model of atrial edema induced by TPA, being the etha-nolic extract and the fraction of dicholoromethane those that presented a moderate anti-inflammatory effect of 49.3 % and 39.8% respectivel.

Palavras-chave : Cavendishia compacta; Ericaceae; antiinflammatory activity.

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