Abstract

LOPEZ, Anthony; HERAZO, Katerine  and  SOTOMAYOR, Reinaldo G.. Design and development of a liquids self emulsyfing drug delivery system of ibuprofen incorporated by the method adsorption by carriers in solids dosage forms. Rev. colomb. cienc. quim. farm. [online]. 2019, vol.48, n.3, pp.589-614.  Epub Nov 03, 2020. ISSN 0034-7418.  https://doi.org/10.15446/rcciquifa.v48n3.84960.

Ibuprofen is one of the most used drugs and it's indicated for anti-inflammatory therapies and pain, among other pathologies. However, this drug has a low and erratic bioavailability, due to its poor aqueous intrinsic solubility, which is categorized as class II in the Biopharmaceutical Classification System. The objective of this work was to develop, design and evaluate a self-emulsifying drug delivery system (SEDDS) to improve the solubility and dissolution rate of ibuprofen.

Oils, co-solvents, surfactants and carriers were evaluated for their ability to improve the solubility of ibuprofen, self-emulsification ability, robustness at different pH levels and adsorption capacity. Coconut oil, Tween 80 and propylene glycol achieved a significant increase in the aqueous solubility of ibuprofen in a self-emulsification time of less than 2 minutes. Neusilin US2® was selected as carrier, resulting in a small granule of excellent fluidity, which allowed to obtain tablets that satisfactorily fulfilled the control tests according to the established specifications. The liquid and solid SEDDS are an advantageous and promising formulation alternative to improve the solubility of poorly soluble drugs according to the biopharmaceutical classification system, through their solubilization properties.

Keywords : Ibuprofen; solubility; self-emulsifying drug delivery system.

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