Abstract

BURGOS-FLOREZ, Francisco Javier  and  DE LAS SALAS, Roxana. A prototype of a low-cost eyelid cleaning foaming solution for symptom management in patients with chronic blepharitis: An I-optimal mixture experimental design. Rev. colomb. cienc. quim. farm. [online]. 2019, vol.48, n.3, pp.615-642.  Epub Nov 03, 2020. ISSN 0034-7418.  https://doi.org/10.15446/rcciquifa.v48n3.84982.

Blepharitis is a common chronic eye condition that causes eyelid inflammation, leading to inflamed, irritated, sticky and itchy eyelids and flaking of the skin. For its treatment, patients often need indefinite use of an eyelid cleaning solution which usually cost more than 20 USD per 80 ml bottle and lasts, on average, one month. For those patients unable to afford the treatment, physicians recommend the use of a do it yourself (DIY) solution. However, the efficacy of DIY eyelid solutions might fluctuate according to the type of blepharitis present in the patient and inadequate pH stabilization of the solution might promote additional itchiness, irritation, and dryness of the skin and eyes. Thus, we propose an optimized DIY solution prototype for symptom management in patients with chronic blepharitis. The formulation contains a significant ratio of tea tree oil and resulted in suitable pH and foam expansion values. The low cost and ease of preparation of the designed formulation make it an affordable, effective alternative in the treatment of chronic blepharitis.

Keywords : Blepharitis; mixture design; I-optimal; foaming solutions; tea tree oil; sodium lauryl sulfate.

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