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Revista Colombiana de Ciencias Químico - Farmacéuticas

Print version ISSN 0034-7418On-line version ISSN 1909-6356


MARTINEZ CARMONA, Dina Marcela  and  TOBON ZAPATA, Gloria Elena. Incorporation of a novel tinidazole complex with antimicrobial properties into two semi-solid topical forms. Rev. colomb. cienc. quim. farm. [online]. 2021, vol.50, n.2, pp.490-504.  Epub Nov 05, 2021. ISSN 0034-7418.


The increase in bacterial resistance to antibiotics commonly used for the treatment of skin infections highlights the need to find alternative and effective drugs, capable of counteracting this health problem that not only involves a region but has become into a global health problem. A novel complex based on tinidazole and copper ([Cu(tnz)2(NO3)2]) has been shown to have good antimicrobial activity, however, in order to be used as an alternative for topical use, it must have the characteristics necessary to be incorporated into a formulation that allows its application.


Semi-solid pharmaceutical forms are the most widely used group within dermatological formulations; Two types of formulations were elaborated, one type of cream and the other cream-gel, in order to verify in which of them the complex [Cu(tnz)2(NO3)2] is conveniently incorporated. For both formulations, the organoleptic properties, pH, area of extensibility, viscosity, and particle size of the complex were determined.


Obtained show the advantages of the cream-type formulation compared to the cream-gel.

Keywords : Complex; cream; cream-gel; extensibility.

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