Servicios Personalizados
Revista
Articulo
Inglés (pdf)
Articulo en XML
Referencias del artículo
Traducción automática
Enviar articulo por emailIndicadores
Citado por SciELO 
Accesos
Links relacionados
Citado por Google 
Similares en
SciELO 
Similares en Google
Compartir
Permalink
Revista Colombiana de Ciencias Químico - Farmacéuticas
versión impresa ISSN 0034-7418versión On-line ISSN 1909-6356
Resumen
SILVA, Georgtown Almir Oliveira da; ARAUJO, Cleônia Roberta Melo y GONSALVES, Arlan de Assis. Evaluation of eggshell membrane as an alternative biopolymeric matrix for delivery of nimesulide. Rev. colomb. cienc. quim. farm. [online]. 2021, vol.50, n.2, pp.550-570. Epub 05-Nov-2021. ISSN 0034-7418. https://doi.org/10.15446/rcciquifa.v50n2.91038.
Introduction:
Eggshell membrane (ESM) is a tissue found between the eggshell and the albumen of eggs that has attractive properties for use in drug delivery systems.
Aim:
To incorporate in ESM and used it as a model drug in release studies. The color change and FTIR analysis of the biopolymer proved the incorporation of nimesulide in ESM.
Results:
The drug uptake was 176.83 and 122.69 mg g-1 by natural and cross-linked ESM. Release studies were carried out using a spectrophotometric flow system in simulated intestinal fluid pH 7.4. The release profiles showed that after 60 minutes 54.55 and 42.58 % of the drug were released from natural and cross-linked ESM, respectively. Kinetics parameters indicated that drug release was better described by the Higuchi model and through a non-Fickian release.
Conclusion:
Considering these results is proved that ESM has the potential to become a polymeric matrix for drug release systems.
Palabras clave : Nimesulide; biopolymer; cross-linking; release kinetics.
