Revista Colombiana de Obstetricia y Ginecología
versão impressa ISSN 0034-7434
RINCON, Olga L; PAREJA, Luis René; JARAMILLO, Sergio e ARISTIZABAL, Beatriz H. Human papillomavirus, immune response and cervical cancer: a complex relationship. Rev Colomb Obstet Ginecol [online]. 2007, vol.58, n.3, pp. 202-212. ISSN 0034-7434.
Cervical cancer is considered to be a serious public health problem having a high incidence in developing countries. High-risk cervical human papillomavirus (HPV) infection, permanence and replication are closely related to the development of cervical cancer. The immune system is able to control and clear such infection in normal conditions by innate immunity action, activating a cellular response and creating antibodies, mainly directed against virion capsid proteins (L1 and L2). In spite of the hosts entire immune protection machinery, the virus can take evasion strategies, maintaining a reduced number of copies in proliferating base cells and taking advantage of the keratinocytes short natural life. This review attempts to show the hosts different immunological mechanisms elicited in response to HPV infection.
Palavras-chave : human papillomavirus; natural and acquired immunity; cervical infection; cervical cancer; keratinocyte.