Revista Colombiana de Obstetricia y Ginecología
versión impresa ISSN 0034-7434
SOLIS, José Antonio et al. Prognosis of stage IIB-IIIB cervical cancer treated with radiochemotherapy: experience from the Van Buren Hospital, Valparaíso, Chile. Rev Colomb Obstet Ginecol [online]. 2007, vol.58, n.4, pp. 268-276. ISSN 0034-7434.
Objective: a retrospective study analysed results and prognostic factors regarding patients suffering from stage IIB-IIIB cervical carcinoma treated with cisplatin-based chemotherapy concurrently with standard radiotherapy. Material and methods: 164 patients were admitted to the hospital from September 1999 to December 2002 who had been diagnosed with cervical cancer; 83 patients suffering from stage IIB-IIIB were selected. Treatment consisted of radiotherapy plus weekly cisplatin-based chemotherapy lasting five weeks. Results: 89.15% of the patients received 5 cycles of chemotherapy. Median overall survival rate was 41 months, with 68.8% 3-year overall survival, 66.3% disease-free survival and 83.1% loco-regional disease-free survival rates. Prognostic factors for survival were: stage IIIB, ≥ 7 cm clinical tumour diameter, patients who had not undergone brachytherapy and biparametrial disease Conclusions: a radiation treatment and concurrent weekly cisplatin therapy regimen in patients suffering from stage IIB-IIIB cervical carcinoma proved feasible in the Carlos Van Buren Hospital (Chilean public health system) having good tolerance, results and prognostic factors similar to those reported in the international literature.
Palabras llave : locally-advanced cervical cancer; chemo-radiation; cisplatin.