Revista Colombiana de Obstetricia y Ginecología
versão impressa ISSN 0034-7434
KUZMAR-DAZA, Leyla Margarita; DIAZ-YAMAL, Ivonne e PEREZ-AGUDELO, Luis Ernesto. Polycystic ovary syndrome and its potential role in the pathogenesis of pregnancy-induced hypertension. Rev Colomb Obstet Ginecol [online]. 2007, vol.58, n.4, pp. 309-315. ISSN 0034-7434.
Pregnancy-induced hypertension which includes both gestational hypertension and preeclampsia is a common and morbid pregnancy complication for which the pathogenesis remains unclear. Many features of polycystic ovary syndrome have been associated with this condition; these would include hypertension, hyper-insulinaemia, glucose intolerance, obesity and lipid abnormalities. Other accompanying abnormalities may include increased leptin levels, tissue necrosis factor, tissue plasminogen activator, plasminogen activator inhibitor-1 and testosterone. Documenting these alterations before the onset of hypertension in pregnancy suggests that insulin resistance or associated abnormalities may play a role in this disorders pathogenesis. Furthermore, recognising that insulin resistance syndrome features persist many years after pregnancy, amongst women having this condition, raises the possibility that these women may have an increased risk of future cardiovascular disease. These observations suggest that interventions to reduce insulin resistance may reduce the risk of hypertension in pregnancy and later-life cardiovascular complications.
Palavras-chave : pregnancy-induced hypertension; preeclampsia; polycystic ovary syndrome; insulin resistance.