Revista Colombiana de Obstetricia y Ginecología
versión impresa ISSN 0034-7434
RAMIREZ-CHEYNE, Julián; PACHAJOA, Harry; ISAZA, Carolina y SALDARRIAGA, Wilmar. Is aglossia adactylia syndrome and prenatal exposure to misoprostol a causal or casual relationship?: A case report. Rev Colomb Obstet Ginecol [online]. 2008, vol.59, n.3, pp. 248-252. ISSN 0034-7434.
Introduction and objective: thea glossiaa dactylia syndrome is an infrequently occurring congenital polymalformative syndrome, having nuclear aetiology and inheritance pattern. A bibliographical search was carried out, orientated towards the association between the prenatal exposure to misoprostol and congenital malformations. A case of this syndrome is presented which was associated with prenatal exposure to misoprostol during the 10th week of gestation; such association has not been established in the literature reviewed. Presentation of the case: a newborn having phenotypical aglossia adactylia syndrome characteristics, the son of a 17-year-old mother having antecedents of having used a 400 microgram oral dose and a 200 microgram vaginal dose of misoprostol at 10 weeks gestation with the aim of interrupting her pregnancy. Discussion: misoprostol is a synthetic prostaglandin E1 analogue; it has been associated with increased risk of Moebius sequence occurring, arthrogryposis, aglossia adactylia syndrome and terminal and cross-sectional extremity defects in mothers who have used this drug during their first gestation trimester.
Palabras llave : congenital defect; misoprostol; pregnancy.