Revista Colombiana de Obstetricia y Ginecología
versão impressa ISSN 0034-7434
VILLARREAL-TORDECILLA, Gustavo Alfonso. Hyperandrogenic states: a literature review. Rev Colomb Obstet Ginecol [online]. 2009, vol.60, n.4, pp. 357-364. ISSN 0034-7434.
Objectives: reviewing the pathophysiology, aetiology, clinical features, diagnosis and treatment of hyperandrogenic states. Methodology: an online search was carried out of literature in PubMed/Medline, published in English or Spanish from 1990 to 2009 regarding research articles, assessing the pathophysiology, aetiology, clinical features, diagnosis and treatment of hyperandrogenic states. Their summaries were then used for analysing them. Results: androgen excess may result from changes in androgen transportation, blockage of androgen conversion into estrogens, altered final response and through exogenous administration. It mostly originates in the ovaries and adrenals an disclinically expressed at the pilosebaceous unit, reproductive and metabolic levels. These states have a negative aesthetic, reproductive, metabolic and/or cardiovascular impact. Proper diagnosis requires a hormone profile plus imaging studies. Some organisations provide specific treatment, while others rather focus on the predominant symptoms. Conclusions: excess androgens pathophysiology and aetiology vary widely, and the clinical picture and consequences it produces require a multidisciplinary approach for both its study and management.
Palavras-chave : hyperandrogenism; insulin resistance.