Abstract

MONDRAGON-CEDENO, Alba Lucía et al. Osseous metaplasia of the endometrium: case reports and literature review. Rev Colomb Obstet Ginecol [online]. 2011, vol.62, n.3, pp.255-260. ISSN 0034-7434.

Objective: presenting two cases and reviewing the pertinent literature concerning the methods used in diagnosing the entity and its etiology. Clinical cases: the cases were attended in the third-level San José teaching hospital where they had been referred due to infertility and chronic pelvic pain. Their echographies revealed hyperechogenic images in the endometrium. Hysteroscopy was performed, revealing multiple osseous formations floating within the endometrial cavity; these were extracted with grasper tweezers and their histological sections confirmed a diagnosis of osseous metaplasia of the endometrium. The first woman became pregnant 8 months later, delivering a healthy newborn at full-term; the second woman became pregnant twice but her attempts ended in complete early abortions. Materials and methods: a search was made of MEDLINE databases via PUBMED, SciELO and Ovid, including articles published during the last 15 years. Conclusion: osseous metaplasia is a cause of infertility involving cellular differentiation of secondary endometrial stromal (stem) cells leading to superoxide dismutase deficiency; this is suspected by transvaginal echography (ultrasound) and should be diagnosed and treated with hysteroscopy.

Keywords : osseous metaplasia; endometrial ossification; osseous ectopy; infertility; hysteroscopy; chronic pelvic pain; abnormal uterine hemorrhage.

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