Abstract

NAVARRO-NEWBALL, Hernando; GARCIA-GUTIERREZ, William  and  PAREDES-BECERRA, Eliana. Molecular aspects and mechanism of action regarding the use of fibrin sealants in laparoscopic gynecology: a literature review. Rev Colomb Obstet Ginecol [online]. 2011, vol.62, n.4, pp.321-325. ISSN 0034-7434.

Objective: reviewing fibrin sealants’ biological activity and mechanism of action related to laparoscopic gynecology. Materials and methods: a search was made of the literature published in both English and Spanish via PubMed/Medline, OVID and Cochrane from 1993 to 2010. Articles involving the use of sealants in laparoscopic gynecology were analyzed and grouped by topic, such as background, biological activity, composition, administration and biophysical characteristics. Results: 200 articles were found which had been published from 1993 to 2010, 49 of them complied with the established analysis criteria. Fibrin sealants contributed towards achieving hemostasis, increasing plasminogen activator and inhibitor expression in peritoneal cells, thereby affecting curing, which could be beneficial in reducing post-operative adhesion. Conclusion: developing fibrin sealants emerges as a practical alternative for reducing hemorrhage and controlling hemostasia, as well as reducing postoperative adhesion in surgery involving laparoscopic gynecology.

Keywords : fibrin sealant; haemostatic; adhesive; gynecology.

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