Abstract

MARQUEZ-LAZARO, Johana; VIOLA-RHENALS, Maricela  and  MONTERROSA-CASTRO, Álvaro. Association between pelvic endometriosis and oxidative stress. Rev Colomb Obstet Ginecol [online]. 2013, vol.64, n.2, pp.178-189. ISSN 0034-7434.

Objective: To determine the current state of knowledge regarding the association between pelvic endometriosis and oxidative stress. Materials and methods: A search on the topic was conducted in the Sciencedirect and Medline databases through Pubmed. Studies published in the English language between January 1990 and June 2012 assessing the association between oxidative stress and pelvic endometriosis were selected. Results: Of a total of 984 abstracts identified, 201 were selected because they contained related information. Overall, 110 complete articles were assessed and, of them, 45 that contained relevant information consistent with the objective of the review were taken into account. There are studies in experimental models and in humans suggesting the potential involvement of oxidative stress in the pathophysiology of pelvic endometriosis. Different studies point to the fact that women with endometriosis-associated infertility have higher levels of pro-oxidants and lower levels of anti-oxidants when compared with healthy controls, as measured in peritoneal fluid or endometrial tissue; these levels are not consistent plasma or serum levels. Conclusions: The role of reactive oxygen species in pelvic endometriosis is yet unclear. This field opens an interesting possibility for research in basic and applied science.

Keywords : Endometriosis; oxidative stress; infertility; reactive oxygen species.

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