Abstract

RUIZ-HOYOS, Bayron Manuel; GIRALDO-GARCIA, Alejandra  and  LANDAZURI, Patricia. Leptin levels in the first and second half of pregnancy in women in Armenia, Colombia, 2011: Cohort study. Rev Colomb Obstet Ginecol [online]. 2014, vol.65, n.1, pp.41-46. ISSN 0034-7434.  https://doi.org/10.18597/rcog.78.

Introduction: Leptin has been associated with pregnancy and its complications. Levels rise and are found to be higher in obese pregnant women and macrosomic neonates. Objective: To describe leptin levels during the first and second half of pregnancy in a cohort of 70 women in Armenia, Quindío. Materials and methods: Descriptive study in a cohort of pregnant women coming for prenatal consultation before week 15 to a level I healthcare center in Armenia, between April 2010 and March 2011. Patients diagnosed with diabetes before becoming pregnant were excluded. Intentional sampling was made including the women who agreed to participate during the study period, after obtaining the informed consent. Procedure: baseline leptin measurement upon entering the study and again on weeks 28-30, with clinical record monitoring until the end of pregnancy. Variables: Leptin levels, maternal BMI, and weight of the newborn. Analysis: Frequency distributions, central trend measurements, Pearson index, and t test for related samples were used. Results: There was a significant increase in leptin levels in the third trimester compared to entry levels (20.4 ng/ml vs. 39.3 ng/ml). Three of the pregnant women were obese, there were nine C-section deliveries, two macrosomic neonates, and two low birth-weight newborns. No correlation was found between leptin and neonatal weight or maternal BMI using the Pearson index. Conclusions: Leptin levels increased significantly during the second half of the pregnancy; there was no correlation with other variables.

Keywords : Leptin; gestation.

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