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Revista Colombiana de Obstetricia y Ginecología

Print version ISSN 0034-7434

Abstract

VASQUEZ-ARENAS, Mónica Isabel; ECHEVERRI-ALVAREZ, Lina; RENDON-PEREIRA, Gabriel  and  PAREJA-FRANCO, Rene. Neo-adjuvant chemotherapy as treatment for fertility preservation in patients with stage IB cervical cancer: Case presentation and review of the literature. Rev Colomb Obstet Ginecol [online]. 2015, vol.66, n.2, pp.124-130. ISSN 0034-7434.  http://dx.doi.org/10.18597/rcog.15.

Objective: To present the case of a patient with stage IB1 cervical cancer larger than 2 centimetres who received neo-adjuvant chemotherapy followed by laparoscopic radical cervicectomy and pelvic lymphadenectomy for fertility preservation; and to review the literature for case reports emphasizing obstetric and oncologic outcomes. Materials and methods: Case presentation and search of the literature in Medline through PubMed of articles published in English, French and Spanish between January 2000 and August 2014 on the topic of neo-adjuvant chemotherapy and fertility preservation surgery in patients with stage IB cervical cancer. Results: Overall, 12 relevant articles were selected totalling 55 patients. Over follow-up period ranging between 14 and 69 months there were 4 relapses and only one death attributable to the disease. Obstetric outcomes included 30 pregnancies, 24 births, 3 miscarriages, 1 ectopic pregnancy, and 2 on going pregnancies. Conclusion: Neo-adjuvant chemotherapy followed by conservative, fertility preservation surgery may be an option for the management of selected patients with stage IB cervical cancer involving large tumours sizes, who wish to preserve their fertility.

Keywords : Fertility preservation; uterine cervix neoplasms; chemotherapy; neo-adjuvant therapy; laparoscopy.

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