Abstract

RIVAS-PERDOMO, Edgar E. Association between older maternal age and adverse perinatal outcomes in a university clinic in Cartagena, Colombia, 2012: A retrospective cohort study. Rev Colomb Obstet Ginecol [online]. 2015, vol.66, n.3, pp.179-185. ISSN 0034-7434.  https://doi.org/10.18597/rcog.22.

Objective: To evaluate the potential association between older maternal age and adverse perinatal outcomes. Materials and methods: Observational historical cohort study of pregnant women delivered during 2012 at the San Juan de Dios University Clinic in Cartagena, a private, level III general care institution. Sample size: 160 patients per group based on an expected frequency of foetal demise of 22% in the exposed group and 10% in the non-exposed group, a 95% confidence interval, and a power of 80%, the number of patients required in each group was 160. A simple random assignment was used. Demographic variables, gestational age at the time of delivery, weight and height of the neonates, 5 minute Apgar, and route of delivery were measured. Foetal death in utero was considered as the primary perinatal adverse outcome, and preterm delivery and perinatal asphyxia were considered as secondary adverse outcomes. The baseline characteristics of the two groups are described. Relative risk (RR) and the corresponding 95% confidence interval were estimated in order to assess the association with the outcomes. Results: The relative risk (RR) of intrauterine foetal demise given older maternal age was 1.33; 95% CI (0.59-2.99). The RR of prematurity given older maternal age was 0.94; 95% CI (0.42-2.05); and the RR of perinatal asphyxia given older maternal age was 0.96; 95% CI (0.66-1.39). Conclusion: Maternal age was not found to be a risk factor for poor perinatal outcomes.

Keywords : Older maternal age; foetal demise; perinatal asphyxia.

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