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Revista Colombiana de Obstetricia y Ginecología

Print version ISSN 0034-7434

Abstract

GONZALEZ-TESHIMA, Laura Yuriko et al. Hereditary breast and ovarian cancer syndrome: Clinical application. Rev Colomb Obstet Ginecol [online]. 2016, vol.67, n.1, pp.36-49. ISSN 0034-7434.  http://dx.doi.org/10.18597/rcog.368.

Objective: To provide gynaecologists with tools for the identification of patients at risk of hereditary breast and ovarian cancer syndrome (HBOC) and present advise regarding the preventive management of patients with this syndrome. Materials and methods: Questions were asked in relation to the risk of patients with HBOC developing breast and ovarian cancer. To answer those questions, a review of the relevant literature was conducted in the Medline database via PubMed, and in ScienceDirect and SciELO. The MESH terms used were Breast and Ovarian Cancer Syndrome, Ovarian Neoplasms, Breast Neoplasms, BRCA1 Genes, BRCA2 Genes, and their equivalent in English. Results were limited to articles published between 2005 and 2015. Results: Overall, 56 articles were found in PubMed, of which 45 were selected. The search in ScienceDirect and SciELO resulted in 7 articles. Additionally, 4 articles from other sources not linked to these data bases were also included. Conclusions: Obstetric gynaecologists must identify patients at risk of presenting Hereditary Breast and Ovarian Cancer Syndrome, and explain to the patients the importance of performing molecular testing for BRCA1 and BRCA2 genes; and they must participate in multi-disciplinary teams consisting also of geneticists, surgeons, oncologists and patients for medical decision-making in accordance with the molecular results.

Keywords : Hereditary breast and ovarian cancer syndrome; ovarian neoplasms; breast neoplasms; BRCA1 and BRCA2 Genes.

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