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Revista Colombiana de Obstetricia y Ginecología

Print version ISSN 0034-7434


CORTES-YEPES, Hernán. Concordance study between placental alpha microglobulin-1 (PAMG-1) and insulin-like growth factor-1 (IGFBP-1) tests in patients with uncertain diagnosis of rupture of membranes, Medellín, Colombia. Rev Colomb Obstet Ginecol [online]. 2016, vol.67, n.4, pp.299-304. ISSN 0034-7434.


To assess diagnostic concordance between placental alpha macroglobulin-1 (PAMG-1) and insulin-like growth factor-binding protein 1 (IGFBP-1) tests in patients with uncertain diagnosis of rupture of membranes.

Materials and methods:

Diagnostic concordance cross-sectional study in pregnant women with clinical suspicion of rupture of membranes seen at Hospital Universitario San Vicente Fundación de Medellín (HUSVF) between August 2014 and December 2015, in whom two diagnostic tests for the diagnosis of rupture of membranes were compared. Patients in advanced labour were excluded. Concordance of test results was estimated in terms of the presence or not of ruptured membranes, using the Kappa Index.


Of 83 patients, 27.7 % were positive for rupture of membranes when the PAMG-1 (Amnisure) was used and 28.9 % were positive with the IGFBP-1 (Actim-Prom) test; the only case of disparity was positive to amniotic infusion of indigo carmine. Concordance between both tests was 0.97.


The performance of IGFBP-1 was similar to that of PAMG-1 for diagnosing rupture of membranes.

Keywords : Premature rupture of membranes; diagnosis; diagnostic tests; indigo carmine.

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