Abstract

CACABELOS, RAMÓN. ALZHEIMER'S DISEASE CURRENT THERAPY AND FUTURE CHALLENGES (FIRST PART). rev.colomb.psiquiatr. [online]. 2001, vol.30, n.3, pp.215-238. ISSN 0034-7450.

In the last 20 years, Alzheimer's disease is no longer the paradigme of normal brain ageing -even though premature and fast. It became an authentic disease, nosologically well defined, and with a dear genetic root. Nowadays, this disease affects more than 20 million people, with enormous economical consequences in different countries and constitutes one of the more active topics of research in the field of health. This paper is a review of the current knowledge on the subject. The first part studies its epidemiology, pathogenia and genetics; priority topics of investigation are here listed; links betweenn Alzheimer and programmed cell death (apoptosis) are discussed, and essential diagnostic elements are presented.

Keywords : Alzheimer's Disease; Dementia; Genetics; Therapeutics.

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