Resumo

OSPINA-DUQUE, J et al. GENETIC LOCI ASSOCIATED TO BIPOLAR DISORDER. STUDIES IN COLOMBIAN POPULATION. rev.colomb.psiquiatr. [online]. 2001, vol.30, n.3, pp.239-248. ISSN 0034-7450.

Objectives: To characterize a sample of families and trios from an isolated colombian population, in order to map loci involved in vulnerability to Bipolar Mood Disorder type-I (BD-I). Methods: Trios and pedigrees using FIGS-DIGS interviews to family members and possibly affected were collected. Power to detect linkage (PDL) was estimated by simulation. Model used supposes an effecter allele frequency of 0.003, penetrances of 0.01, 0.81, 0.9 and a 4-allele marker at 5cM of the locus. Results: 28 BD-I families including 3.603 individuals and 160 affected, and 246 trios were identified. Assuming genetic homogeneity and our recently found genetic cross breeding, simulations revealed meaningful PDL of 100% for LOD-score>3. We are now assessing background unbalance in trios, and screening families for chromosomes 12,18 and 21. Conclusion: We have an informative set of BD-I families and trios belonging to an isolated population, which allow further linkage studies associated with BD-I in Colombian population.

Palavras-chave : Bipolar Mood Disorder; Locus; Genetic.

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