Abstract

CONTRERAS ZUNIGA, Eduardo; ZULUAGA MARTINEZ, Sandra Ximena  and  OCAMPO, Vanesa. Toxic Epidermic Necrolysis Secondary to the Use of Olanzapine: Case Report. rev.colomb.psiquiatr. [online]. 2008, vol.37, n.3, pp.468-474. ISSN 0034-7450.

Introduction: In 1956, Alan Lyell used the term toxic epidermal necrolysis (TEN) to describe a histological and clinical pattern characterized by necrosis of the epidermis, diffuse epidermolysis with exfoliation and/or training bulosas injuries, as well as noncutaneous manifestations such as hydro electrolytic, thermoregulatory and catabolic impairment. Objective: To describe a clinical case with a larger and unusual reaction, secondary to the use of olanzapine. Methods: Search for information in the databases: PubMed/Medline, Cochrane, SciELO, as well as in references from journals articles and textbooks, mainly in the last five years. 16 articles were reviewed, 10 of which were included in the discussion. Results: The secondary reactions in the skin due to the use Olanzapine are present in <0,5% of patients who consumed it; however these reactions vary from a rash to TEN with a high risk of death. Conclusion: The skin is the organ most frequently affected by adverse reactions to medicines. However, only a small percentage of skin reactions are serious and life threatening. The low incidence of these reactions are unlikely to be detected in clinical trials prior to the marketing of medicines. The use of various drugs has been described as responsible for the occurrence of serious skin reactions.

Keywords : Toxic epidermal necrolysis; drug eruptions; olanzapine.

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