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Revista Colombiana de Psiquiatría

Print version ISSN 0034-7450


GIL, Laura et al. Characterization of P300 Wave in Colombian Patients with a Schizophrenia Diagnose. rev.colomb.psiquiatr. [online]. 2009, vol.38, n.3, pp.433-445. ISSN 0034-7450.

Objetive: To assess the P300 wave amplitude and latency in a group of patients dianosed with schizophrenia. Methods: A group of 36 schizophrenic patients in remission stage and the same number of healthy controls were selected, paired by age and sex, with NO personal history of neurologic disease and NO family history of psychiatric disorders. Cognitive event-related potentials were performed to obtain the P300 wave amplitude and latency, USING four active electrodes PLACED at F3, Fz, Cz and Pz, according to the 10-20 electroencephalographic system. A repeatedmeasures ANOVA test was used to evaluate the differences between the groups Results: A decreased amplitud and a prolonged latency in all electrodes were found in the patient group. The differences were statistically significant (<0.05). Conclusion: This is the first study on P300 wave in schizophrenia performed in Colombia. Similar results to those reported in other international case-control studies were found and, as such, it was concluded that the P300 wave abnormalities in patients with schizophrenia may be considered as an endophenotype, or a biological marker of this disorder that would allow using this methodology in other types of biological studies. However, the low specificity of this technique limits its use as a diagnostic test.

Keywords : Amplitude; event-related potentials; reaction time; schizophrenia.

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