Abstract

FORERO CASTRO, Ruth Maribel; CORTES DUQUE, Carolina; SANCHEZ ESPINOSA, Mayely Paola  and  CORREDOR ROZO, Zayda Lorena. Cromosomal Abnormalities and Schizophrenia. rev.colomb.psiquiatr. [online]. 2009, vol.38, n.3, pp.534-554. ISSN 0034-7450.

Introduction: Schizophrenia is a mental disorder that affects the world population with a prevalence of 1% and a hereditability of up to 80% . Four approaches have been postulated to identify susceptibility genes and to establish molecular markers associated with the disease: Genetic linkage studies, genomic convergence, association, and chromosomal abnormalities. Objective: To show chromosomal abnormalities reported in patients with schizophrenia as part of the genetic factors found in this condition. Methods: A strategic selection was made of 68 articles published from 1954 to 2008 in scientific databases, and numerical, structural and mosaical type alterations were classified, taking into account their contributions to the study and relevance. Results: The mainly involved chromosomes were, in order of frequency, 18, 9, 11, 1, X, 22 and 21. As to type of abnormalities, structural and numerical alterations were found, as well as mosaicims and polymorphisms. Conclusions: With this review not only the calculation of the frequency of these findings was made more possible, but it also provided a reference of the type and frequency of these alterations to evaluate the genetic factor of schizophrenia, aimed at understanding its pathogeny

Keywords : Schizophrenia; chromosomal aberrations; cytogenetic analysis.

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