Abstract

OROZCO-CABAL, Luis Felipe. The Hardness of Hard Science: Truth or Myth?. rev.colomb.psiquiatr. [online]. 2010, vol.39, n.1, pp.178-189. ISSN 0034-7450.

Objective: To discuss methodological issues concerning the quality and applicability of clinical research and evidence-based medicine principles to pre-clinical research. Methods: Critical analysis of selected writings. Results: Rigorous standards to determine the quality and generalization of pre-clinical findings are needed; methods to systematically review the evidence and its weight have not been developed for pre-clinical research. Conclusions: Never before has a debate about the limitations of pre-clinical research been more relevant, given the momentousness of its contributions and its obligation towards the well-being of humankind

Keywords : Methodology; evidence-based medicine; research.

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