Revista Colombiana de Psiquiatría
versão impressa ISSN 0034-7450
GONZALEZ, Gerardo e ROMERO-GONZALEZ, Mauricio. Pharmacological Alternatives for the Treatment of Heroin Dependence: A New Challenge in Colombia. rev.colomb.psiquiatr. [online]. 2010, vol.39, suppl.1, pp. 188s-212s. ISSN 0034-7450.
Introduction: In Colombia, the prevalence of problems associated with heroin dependence has increased since the nineties. Method: After contextualize this issue, the article focuses on the scientific findings, indications, and pharmacotherapeutic limitations of the range of existing medications to treat acute withdrawal syndrome, commonly known as detoxification. Results: The pharmacological options available include opioid agonists, opioid partial agonists, antagonists and alpha-2 adrenergic agonists. Conclusion: Although the comprehensive treatment of heroin dependence include psychotherapeutic interventions, this review indicates that the approach, perhaps more successful in controlling acute withdrawal syndrome after abrupt discontinuation of heroin is methadone or buprenorphine followed by a gradual reductionin dose, while promoting lifestyle changes sustainable and relapse prevention.
Palavras-chave : Heroin; opiate; opiate; pharmacotherapy.