Abstract

MONTOYA, Iván D.. Research Advances in the Immunotherapies of Addictions. rev.colomb.psiquiatr. [online]. 2010, vol.39, suppl.1, pp.213s-223s. ISSN 0034-7450.

Introduction: Immunological therapies, either with vaccines (active immunization) or with antibodies (passive immunization), are being actively investigated in the management of complications of drug abuse. Objetive: To review the current state of research development of immunotherapies against nicotine, cocaine, heroin, methamphetamine and phencyclidine (PCP) with an emphasis on the clinical aspects. Method: Review the literature about the topic. Results: So far, immunotherapies evaluated in humans appear to be safe from a medical standpoint and effective. This mechanism prevents the activation of brain reinforcement mechanisms associated with the addictive effects of drugs and, eventually, the extinction of the drug addiction. Conclusion: In theory, vaccines could also be useful in preventing the development of addiction as well as to prevent the relapse of drug use. Currently, vaccines are being investigated against cocaine, heroin, methamphetamine and nicotine. Likewise, monoclonal antibodies are being investigated against cocaine, methamphetamine, nicotine and phencyclidine (PCP).

Keywords : Immunotherapy; vaccines; drug addiction; treatment.

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