Abstract

CASTANEDA RAMIREZ, Jhon Jairo; CARDONA DEAZA, José Luis; MIRANDA ROSERO, Harold  and  FRANCO LONDONO, Jairo. Myocarditis Due to Clozapine: Case Report and Topic Review Abstract. rev.colomb.psiquiatr. [online]. 2011, vol.40, n.1, pp.170-182. ISSN 0034-7450.

Introduction: Myocarditis is a heart muscle inflammation. There are signs that can help make the diagnosis but, the patient may be asymptomatic or presented with sudden death. Clozapine is indicated for the treatment of refractory schizophrenia, it may cause cardiomyopathies. Objective: To report the case of a 20-year-old who died of myocarditis due to clozapine. Methods: Case report. Results: We describe an asymptomatic case of fatal myocarditis due to clozapine, and we show histological slides of the heart with characteristic eosinophilic infiltration. Discussion: We discuss the manifestations of the entity and how to diagnose it. Conclusions: Although clozapine myocarditis is rare (prevalence: 0,015% - 0,188%). It may occur within 8 weeks of treatment, time which should be actively investigated.

Keywords : Myocarditis; hypersensitivity; clozapine; sudden death.

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