Abstract

VARGAS UPEGUI, Cristian; CORREA-PALACIO, Andrés; GARCIA, Jenny  and  LOPEZ-JARAMILLO, Carlos. Functional Magnetic Resonance Imaging in euthymic Adult Patients with Bipolar Disorder Type I: Neuropsychological and Neurofunctional Aspects. rev.colomb.psiquiatr. [online]. 2011, vol.40, suppl.1, pp.183-197. ISSN 0034-7450.

Introduction: Several studies using functional magnetic resonance imaging during the euthymic phase of bipolar disorder type I have been performed in the last decade. A critical review of the findings is therefore required. Methods: The major databases (Pubmed, EMBASE, Lilacs, and Scielo) were consulted searching studies of fMRI in euthymic adults with Bipolar disorder type I without timeframe limits. Results: The neuroanatomical and neuropsycholo gical findings are presented in two parts: 1) working memory with N_back and Stenberg paradigms, and 2) Executive function with interference in selective attention or Stroop test (word / color, counting and emotional) and inhibitory control with go / no go tasks. Conclusions: The results were contradictory due to differences in paradigms, inclusion criteria, residual symptoms, and history of drugs. Prefrontal dysfunction was identified in the Stroop test and in working memory tasks compared with controls (specifically dorsolateral region) which has been proposed as a feature of the disorder. Frontopolar area (BA 10) appears to be important in frontal dysfunction. Findings in areas such as the anterior cingulate and parietal and ventral prefrontal cortex need to be replicated in subsequent research with a closer control of confounding factors.

Keywords : Functional magnetic resonance imaging; bipolar disorder; euthymia; Stroop; memory.

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