Resumo

MACHADO-ALBA, Jorge E.  e  MORALES-PLAZA, Cristhian David. Prevalence of Avoidable Potential Interactions Between Antidepressants and Other Drugs in Colombian Patients. rev.colomb.psiquiatr. [online]. 2013, vol.42, n.2, pp.162-166. ISSN 0034-7450.

Objectives: To determine the possible drugs interactions with antidepressive agents in data bases of patients in the Health Insurance System of Colombia. Methods: From data bases of about 4 million users in Colombia, a systematic review of drugs dispensation statistics was made to identify drug interactions between antidepressive agents, cholinergic antagonists and tramadol in 2010. Results: We identified 114,465 monthly users of antidepressive agents. Of these, 5776 (5.0 %) received two, and 178 (0.2 %) received three antidepressive agents simultaneously. The most frequent combination was fluoxetine+trazodone (n =3235; 56.9 % of cases). About 1127 (1.0 %) patients were prescribed a cholinergic antagonist simultaneously; 2523 (2.1 %) users were dispensed tramadol at the same time, while raising the risk of serotonin syndrome. Conclusions: Drug interactions represent a potential risk that is often underestimated by physicians. Pharmacovigilance is a useful tool to optimize resources and prevent negative outcomes associated with medication. It is recommended that systematic search is made to enhance surveillance programs for the rational use of medicines in this country.

Palavras-chave : Antidepressive agents; Drug prescriptions; Amitriptyline; Fluoxetine; Trazodone; Cholinergic antagonists; Tramadol; Adverse drug reaction; Colombia; Pharmacovigilance.

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