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Revista Colombiana de Psiquiatría

Print version ISSN 0034-7450

Abstract

ZUNIGA ZAMBRANO, Yenny Carolina  and  VASQUEZ, Rafael. Psychiatric Disorders in Pediatric Patients With Systemic Lupus Erythematosus in a Reference Hospital. rev.colomb.psiquiatr. [online]. 2014, vol.43, n.2, pp.73-79. ISSN 0034-7450.

Objective: To describe the psychiatric manifestations in pediatric patients with systemic erythematous lupus seen in the Fundación Hospital de la Misericordia. Methods: Observational descriptive study. Medical charts and test results of inpatients and outpatients between 2007 and2013 were reviewed; 39 patients were selected. SPSS 19 was used for statistical analysis. Statistical significance was considered with P= .05. Results: Mean age was 13.7 (2.33), with 78.9% female. The most frequent psychiatric manifestation was anxiety (52.6%), followed by adjustment disorder and depression (36.8% each one), psychosis (10%), conversion disorder (7.9%), and obsessive compulsive disorder (5.3%). The mean SLICC score was 2.76 (2.8), and the mean SLEDAI score was 20.81 (20.82). Antinuclear antibodies were positive in 81.25%. Neuropsychiatric lupus was diagnosed in 65.8% of patients; seizures were observed in 23.7%, headache in 36.8%, stroke in 13.2%, vasculitis, chorea 5.3%, and meningitis 5.3% of patients. The mean time from lupus diagnosis was 20.47 (22.2) months, with the shortest period for adjustment disorder and the longest period in patients with conversion disorder (pseudo-seizures) being 15 months and 31 months, respectively. The highest SLEDAI score was in patients with psychosis (35.5 [16.21] vs 19.08 [13.72]; P = .032), and also the highest disease damage (SLICC, 4.25 [4.03] vs 2.58 [2.67]; P = .27) in comparison with the other manifestations. Conclusions: The most frequent psychiatric manifestations were anxiety, depression, and adjustment disorder, with a higher frequency than other studies, and with lupus activity principally in patients with psychosis.

Keywords : Systemic lupus erythematosus; Child psychiatry; Depression; Anxiety disorders; Psychotic disorders.

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