SciELO - Scientific Electronic Library Online

 
vol.43 issue2Psychiatric Disorders in Pediatric Patients With Systemic Lupus Erythematosus in a Reference HospitalEmotional Profile of a Group of Colombian Military Victims of Landmines or Improvised Explosive Devices author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


Revista Colombiana de Psiquiatría

Print version ISSN 0034-7450

Abstract

ARANGO VIANA, Juan Carlos et al. Prevalence of Variants in the Apolipoprotein E (APOE) Gene in a General Population of Adults from an Urban Area of Medellin (Antioquia). rev.colomb.psiquiatr. [online]. 2014, vol.43, n.2, pp.80-86. ISSN 0034-7450.

Objective: To determine the allelic and genotype frequencies of apolipoproteine E (APOE) gene in a representative sample of the adult population of Medellin in 2010. Methods: A representative sample of the adult population of Medellin, was obtained by means of a multi-stage, stratified, conglomerate based sampling method. APOE genotyping was carried out on each of the participants. The sampling design was taken into consideration for the frequencies and association analysis. Results: The frequencies of the APOE alleles E2, E3 and E4 were 3.9, 92.0 and 4.1%, respectively. The frequencies of the different APOE genotypes were as follows: 2/2, 0.2%; 2/3, 6.8%; 2/4, 0.6%; 3/3, 85.0%; 3/4, 7.2%, and 4/4, 0.3%. Conclusions: The allelic and genotype frequencies of APOE in an adult population of Medellin did not differ substantially from other series reported in South America. These data are important to determine the real impact of APOE on the population risk of several psychiatric diseases.

Keywords : Apolipoprotein E; Prevalence; Genetics; Alzheimer disease; Schizophrenia.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )