Abstract

RESTREPO, Diana et al. Rhabdomyolysis in a Bipolar Adolescent. Analysis of Associated Factors. rev.colomb.psiquiatr. [online]. 2015, vol.44, n.3, pp.183-188. ISSN 0034-7450.  https://doi.org/10.10167j.rcp.2015.02.005.

Objective: To describe a case of rhabdomyolysis associated with the use of quetiapine and lamotrigine in an adolescent treated for bipolar disorder. Method: Description of the clinical case, analysis of the associated factors and a nonsystematic review of the relevant literature. Results: An 18 year old male, with bipolar disorder and treated pharmacologically with quetiapine and lamotrigine, after two weeks of physical activity presents with rhabdomyolysis. Quetiapine and exercise have been associated with rhabdomyolysis. The mediator mechanism of this association has not been found, although it has been established that there is neuromuscular dysfunction and an increase in sarcomere permeability. Conclusions: This clinical case allowed the complex interaction between antipsychotic agents and increased physical activity to be observed in a psychiatric adolescent patient, as well as the appearance of a potentially lethal medical complication.

Keywords : Rhabdomyolysis; Exercise; Bipolar disorder; Antipsychotic agents.

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