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Revista Colombiana de Psiquiatría

versão impressa ISSN 0034-7450

Resumo

ORTEGA-ROJAS, Jenny et al. Study of genetic variants in the BDNF, COMT, DAT1 and SERT genes in Colombian children with attention deficit disorder. rev.colomb.psiquiatr. [online]. 2017, vol.46, n.4, pp.222-228. ISSN 0034-7450.  http://dx.doi.org/10.1016/j.rcp.2016.08.006.

Background:

Attention deficit and hyperactive disorder (ADHD) is highly prevalent among children in Bogota City. Both genetic and environmental factors play a very important role in the etiology of ADHD. However, to date few studies have addressed the association of genetic variants and ADHD in the Colombian population.

Objectives:

To test the genetic association between polymorphisms in the DAT1, HTTLPR, COMT and BDNF genes and ADHD in a sample from Bogota City.

Methods:

We genotyped the most common polymorphisms in DAT1, SERT, COMT and BDNF genes associated with ADHD using conventional PCR followed by restriction fragment length polymorphism (RFLP) in 97 trios recruited in a medical center in Bogota. The transmission disequilibrium test (TDT) was used to determine the association between such genetic variants and ADHD.

Results:

The TDT analysis showed that no individual allele of any variant studied has a preferential transmission.

Conclusions:

Our results suggest that the etiology of the ADHD maybe complex and involves several genetic factors. Further studies in other candidate polymorphisms in a larger sample size will improve our knowledge of the ADHD in Colombian population.

Palavras-chave : Polymorphisms; ADHD; TDT; Colombia.

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