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Revista Colombiana de Psiquiatría

versão impressa ISSN 0034-7450

Resumo

ALEEM, Daniyal  e  TOHID, Hassaan. Pro-inflammatory Cytokines, Biomarkers, Genetics and the Immune System: A Mechanistic Approach of Depression and Psoriasis. rev.colomb.psiquiatr. [online]. 2018, vol.47, n.3, pp.177-186. ISSN 0034-7450.  http://dx.doi.org/10.1016/j.rcp.2017.03.002.

Objective:

To highlight the inflammatory and immunological mechanisms involved in depression and psoriasis.

Methods:

A comprehensive literature search was performed in various databases, in total 145 studies were selected.

Results:

Depression and psoriasis have an association. Immune mechanisms -the actions of tumor necrosis factor-a, interleukin 1 (IL-1), IL-2, IL-10, IL-22, IL-17, interferon-7, IL-1ß, prostaglandin E2, C-reactive protein, IL-6, and IL-8 etc.-, and some genetic changes are involved.

Conclusions:

A possible bidirectional relationship of psoriasis and major depression exists; i.e. the depression leads to psoriasis, and psoriasis leads to depression. We recommend more studies in the future to get a deeper and better understanding about this relationship.

Palavras-chave : Depression psoriasis; psychodermatology; neurodermatology; psoriasis and major depression; inflammation depression; inflammation psoriasis.

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