Abstract

BARBOSA EYLER, Gonzalo Emmanuel  and  UTRIA CASTRO, Jhoan Vidal. Zolpidem Dependence and Withdrawal. A Case Report of Generalized Seizures. rev.colomb.psiquiatr. [online]. 2023, vol.52, n.3, pp.265-267.  Epub Nov 11, 2023. ISSN 0034-7450.  https://doi.org/10.1016/j.rcp.2021.06.007.

Zolpidem is a non-benzodiazepine hypnotic agent used most frequently in the treatment of insomnia, indicated for short-term use. It is not indicated for the chronic treatment of sleep disorders, despite which there is evidence in clinical practice that a large number of patients receive it for years. Although it has been described that it presents a better profile of adverse effects than benzodiazepines and that it generates a lower risk of dependence and withdrawal than these, there are significant reports of cases of dependence and withdrawal from zolpidem. A report of a case of generalized tonic-clonic seizures due to with drawal at a dose of 300 mg per day of zolpidem is presented and a brief review of the literature is carried out.

Keywords : Zolpidem; Substance withdrawal syndrome; Seizures.

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