Abstract

GOMEZ ALVAREZ, Carlos Andrés; LEAL CASTRO, Aura Lucía; PEREZ DE GONZALEZ, María de Jesús  and  NAVARRETE JIMENEZ, Myriam Lucía. Resistance mechanisms in Pseudomonas aeruginosa: understanding a dangerous enemy. rev.fac.med. [online]. 2005, vol.53, n.1, pp.27-34. ISSN 0120-0011.

Pseudomonas aeruginosa is a Gram-negative fermentative bacilli related with nosocomial infections. This kind of infections is more frequent in critical ill patients, specially in intensive care units, where a high pressure selection is ejerxed. Nosocomial infections are associated with poor prognosis, increased treatment cost, cubed length, morbidity and mortality. Each health care institution might establish antimicrobial resistance surveillance in order to recognize antimicrobial resistance mechanisms, and transference of resistance of this pathogen. In the other hand, concepts as "interpretative reading" help the clinician to infer the possible mechanisms involved and in this way guide the antimicrobial therapy in order to boarding the challenge of this kind of infections.

Keywords : pseudomonas aeruginosa; resistance mechanisms; expulsion pumps; porines; β-lactamases; antibiotics; defense mechanisms.

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