Abstract

PEREZ, Clara Eugenia  and  GUERRERO, Carlos Arturo. Molecular mechanisms by which free fatty acids might interfere with periferic insuline action. rev.fac.med. [online]. 2005, vol.53, n.2, pp.91-97. ISSN 0120-0011.

Previous research suggests that free fatty acids are implicated in insulin resistance, but the molecular mechanism for it isn't completely elucidated, given the lack of an integrated hypothesis relating all of the proposed mechanisms. At the present time, the causes of insulin resistance, obesity and metabolic syndrome, a common feature in patients with diabetes mellitus are matter of intense study. Among several molecular mechanisms by which the increase in free fatty acids could raise insulin resistance is decrease in xylulose-5-phosphate that leads to an inhibition of phosphofructokinase-2, and consequently to a blockade in glycol sis with a subsequent increase in the final products of the hexosamine pathway and activation of PKC has been proposed as well as known activator of IKKB that inhibits tyrosine phosphorilation of IRS, hindering glucose transport.

Keywords : fatty acids; diabetes mellitus; obesity; insulin; glucose; hyperglycemia; xylulose; glycolysis.

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