Abstract

MENDIVIL ANAYA, Carlos Olimpo  and  SIERRA ARIZA, Iván Darío. Insulin action and resistance: molecular aspects. rev.fac.med. [online]. 2005, vol.53, n.4, pp.235-243. ISSN 0120-0011.

Pathologies associated with chronic metabolic disturbances like obesity, diabetes and dyslipidemia, constitute major contributors to the worldwide burden of disease, death and disability, and are acquiring a higher relevance every day. Several of these problems are a direct or indirect consequence of an insufficient action of insulin, which gives rise to a cluster of risk factors that potentiate the onset of cardiovascular atherosclerotic disease in the long term. This review adresses in a concise way the mechanisms of insulin action at the molecular level, as well as the way they can be affected by factors different to the genetic constitution of each individual.

Keywords : insulin; diabetes mellitus; metabolism; phosphorylation.

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