Revista Facultad de Medicina de la Universidad Nacional de Colombia
Print version ISSN 0120-0011
NARVAEZ QUINTERO, Guillermo Orlando and GUERRERO FONSECA, Carlos Arturo. Molecular bases of experimental immunotoxicology of marijuana . Rev.fac.med.unal [online]. 2006, vol.54, n.4, pp. 290-300. ISSN 0120-0011.
Marijuana is one of the oldest drugs known by humankind; however, only recently the biochemical mechanism behind the toxicodinamics effects have begun becoming clear. The experimental models, in vitro and in vivo, both in animals and humans, show a clear tendency of immune alteration, pointing out suppression of the Th1-dependent immune response. In these events the involvement of cannabinoid receptors on the surface of immunocites are remarkable.
Keywords : cannabis; marijuana abuse; toxicology; biochemical phenomena; cannabinoids; immune system.