Abstract

PEREZ G, Clara Eugenia; MENDIVIL A, Carlos Olimpo  and  SIERRA A, Iván Dario. Influence of clinical and lipid variables on the magnitude of postprandial lipemia in subjects with and without hipertriglyceridemia. rev.fac.med. [online]. 2007, vol.55, n.1, pp.4-13. ISSN 0120-0011.

Introduction. The postprandial lipemia is characterized by some prolonged increase in circulation of triglycerides rich lipoproteins that can produce atherosclerosis, which is an important cause of death in our population. Objective. To evaluate the effect of lipidic and clinical variables on the values of postprandial lipemia in subjects with and without hipertriglyceridemia. Materials and methods. Forty-eight subjects of both sexes were studied, half of them, with basal triglycerides above 200mg/dl, who ingested a standardized lipidic load (breakfast with 30g of fat) and then they were followed during seven hours gathering total blood every hour to determine the level of postprandial triglycerides and the postprandial lipemia values. The later data was correlated with clinical variables as age, body mass index, waist circumference, among other; and with lipidic variable as total cholesterol, HDL, LDL and basal triglycerides. Results. There was alteration in the clearence of postprandial triglycerides in those subjects with a basal concentration of triglycerides above 186 mg/dl. The clinical variables most related tothe magnitude of postprandial lipemia were age (p=0.009) and waist perimeter, while the lipidic variables that were strongly related with the postprandial lipemia were the basal triglycerides concentration (p=<0.001), the VLDL cholesterol (p=<0.001) and the HDL cholesterol(p=0.041). Conclusion. The variables that could predict the behavior of postprandial triglycerides in the individuals of this study are age, waist perimeter, VLDL cholesterol, HDL cholesterol and the basal triglycerides concentration.

Keywords : lipoprotein lipase; triglycerides; hypertriglyceridemia.

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